Mitochondria Support Hippocampal CA2 Neurons

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mitochondrial calcium uniporter

Medical Xpress - medical research advances and health news

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Science

Scientists discover mitochondria's role in shaping memory circuits

Summary

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89% Informative

Mitochondrial dysfunction is a major contributor to neurological disorders such as Alzheimer's disease, autism, schizophrenia, and depression.

The research in mouse models examines the hippocampal CA2 region, a specialized area in the brain's memory center essential for social recognition memory.

The researchers deleted the MCU gene in CA2 neurons of genetically engineered mice.

This caused a disruption in plasticity at the outermost synapses, leading to problems with thinking and memory.

More information: Katy E. Pannoni et al , MCU expression in hippocampal CA2 neurons modulates dendritic mitochondrial morphology and synaptic plasticity, Scientific Reports ( 2025 ). DOI: 10.1038 /s41598-025-85958-4 Provided by Virginia TechThis story was originally published on Medical Xpress . Subscribe to our newsletter for the latest sci-tech news updates..

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English

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