mRNA-based drug delivery for IBD
This is a US news story, published by The Jerusalem Post, that relates primarily to Tel Aviv University news.
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ulcerative colitisThe Jerusalem Post
•Health
Health
TAU makes breakthrough in drug delivery to treat inflammatory bowel disease
74% Informative
Tel Aviv University researchers have successfully delivered mRNA-based drugs to the intestine without passing through the liver.
This groundbreaking development could make possible effective treatments for chronic and incurable inflammatory diseases such as Crohn ’s disease and ulcerative colitis.
About seven million people around the world and 15% of the US population suffer from inflammatory bowel disease (IBD).
Lipid-based drugs are encased in synthetic lipid nanoparticles that mimic biological membranes.
In vaccines, such as the COVID-19 vaccine, the mRNA is encapsulated in lipid particles containing about 10% of phospholipid.
The researchers increased the ratio to 30% causing the particles to float through the bloodstream like oil on water.