Immune System Disruption Linked to Cancer

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Immune Lymphocyte Estimation

ScienceDaily

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Health

New tool reveals disruption of immune cells in blood is linked to cancer outcomes

Summary

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79% Informative

New tool reveals disruption of immune cells in blood is linked to cancer outcomes.

Cancer patients had a lower proportion of T cells circulating in the blood compared to healthy individuals.

T cell proportion was found to be a strong predictor of cancer outcomes, with higher proportions associated with 47% fewer deaths over a five-year period after surgery.

B cells producing IgM/D antibodies in the blood were the only type of B cell associated with improved survival outcomes of cancer patients.

These cells may play a key role in anti-tumour immunity.

They also have potential as a new biological marker for cancer diagnosis.

Robert Bentham , Thomas P. Jones , James R. M. Black , Carlos Martinez-Ruiz , Michelle Dietzen , Maria Litovchenko , Kerstin Thol , Thomas B. Watkins , Chris Bailey , Oriol Pich , Zhihui Zhang , Mariam Jamal-Hanjani , Carlos Martínez- Ruiz, Peter Van Loo , David A. Moore , Emilia L. Lim , Emma Colliver , Katey S. Enfield , Jacqui A. Shaw , Rachel Rosenthal , Andrew Rowan , Victoria Spanswick , Michelle M. Leung , Gareth A. Wilson .