Comprehensive resource describes functions of more than 20,000 human genes

A comprehensive encyclopedia of the known functions of all protein-coding human genes has just been completed and released on a new website.

Researchers used large-scale evolutionary modeling to integrate data on human genes with genetic data collected from other organisms.

Gene Ontology, a National Institutes of Health -funded knowledge base that has been continually expanded and improved for more than 25 years .

The PAN -GO functionome is not yet complete.

It contains data on 82% of protein-coding genes, but no experimental data exists for the other 18% -- roughly 3,600 genes.

Researchers can now submit suggestions for updating the knowledge base on specific genes through the project's website.

The study was published in the journal Nature Nature .

It is the first of its kind compendium of human gene functions derived from evolutionary modelling.

The study has been published by the International Society for Evolution and Human Genomics , published in Springer, Springer and Nature Publishing House , New York .