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New CRISPR tool enables more seamless gene editing -- and improved disease modeling

ScienceDaily
Summary
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81% Informative

Advances in the gene-editing technology known as CRISPR-Cas9 over the past 15 years have yielded important new insights into the roles that specific genes play in many diseases.

But to date this technology is able to target, delete, replace, or modify only single gene sequences with a single guide RNA and has limited ability to assess multiple genetic changes simultaneously.

Yale scientists have created four new Cas12a mouse lines that will allow researchers to study complex genetic interactions and their effects involved in many disorders.

VR Score

91

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97

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57

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formal

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English

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72

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long-living

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