welcome
Phys Org

Phys Org

Science

Science

How a critical enzyme keeps potentially dangerous genes in check

Phys Org
Summary
Nutrition label

86% Informative

Heterochromatin contains tens of thousands of units of dangerous DNA, known as "transposable elements" Cells have taken advantage of an entire protein network to repress TE activity and keep themselves healthy.

O-GlcNAc transferase (OGT) is an enzyme at the heart of many essential cellular functions.

This is extremely important for controlling TE expression because it prevents the silencing modification 5mC from being converted to the activating modification 5hmC in heterochromatin .

Without OGT at the helm, TET proteins ramp up DNA demethylation in the wrong places, turning on too many genes at once.

This new research may also prove important for future drug development.

VR Score

87

Informative language

89

Neutral language

39

Article tone

formal

Language

English

Language complexity

66

Offensive language

not offensive

Hate speech

not hateful

Attention-grabbing headline

not detected

Known propaganda techniques

not detected

Time-value

long-living

Affiliate links

no affiliate links