Heterochromatin: Dark DNA Role
This is a heterochromatin news story, published by Phys Org, that relates primarily to TE news.
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heterochromatinPhys Org
•Science
Science
How a critical enzyme keeps potentially dangerous genes in check

86% Informative
Heterochromatin contains tens of thousands of units of dangerous DNA, known as "transposable elements" Cells have taken advantage of an entire protein network to repress TE activity and keep themselves healthy.
O-GlcNAc transferase (OGT) is an enzyme at the heart of many essential cellular functions.
This is extremely important for controlling TE expression because it prevents the silencing modification 5mC from being converted to the activating modification 5hmC in heterochromatin .
Without OGT at the helm, TET proteins ramp up DNA demethylation in the wrong places, turning on too many genes at once.
This new research may also prove important for future drug development.
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