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Preventing onset and development of heart failure with preserved ejection fraction

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When the cardioprotective mechanism fails, it promotes the development of HFpEF , a serious condition in need of effective treatment.

The findings provide a promising therapeutic target to prevent and treat this life-threatening disease.

"HFpEF is a complex, multifactorial disease associated with metabolic stress," said co-author Dr. Tamer Mohamed .

XBP1s-EDEM2 Prevents the Onset and Development of HFpEF by Ameliorating Cardiac Lipotoxicity .

Circulation, 2025 ; DOI: 10.1161 /CIRCULATIONAHA.124.072194.