Gut Bacteria Block Cancer Signaling
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gut microbiotaScienceDaily
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Gut microbes release cancer-fighting bile acids that block hormone signals
77% Informative
Bacteria naturally present in the human intestine (known as the gut microbiota) can transform cholesterol-derived bile acids into powerful metabolites that strengthen anti-cancer immunity by blocking androgen signaling.
The study was published on April 15 in Cell .
Bile acids help shrink tumors by enhancing T cells' ability to survive within the tumor and destroy cancer cells.
The team is now focused on controlling the synthesis and release of these beneficial molecules using advanced techniques to genetically engineer gut commensal bacteria.
They aim to understand the broader physiological impact in the host initiated by these androgen blocking, microbiota-derived bile acids.
Microbiota-derived acids antagonize the host androgen receptor and drive anti-tumor immunity.
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