Mitochondrial Mitochondrial Machine Structure Revealed

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human mitochondrial pyruvate carrier

ScienceDaily

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Science

Throwing a 'spanner in the works' of our cells' machinery could help fight cancer, fatty liver disease... and hair loss

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Scientists have worked out how a molecular machine found in mitochondria, the 'powerhouses' of our cells, allows us to make the fuel we need from sugars, a process vital to all life on Earth .

Known as the mitochondrial pyruvate carrier, this molecular machine was first proposed to exist in 1971 , but it has taken until now for scientists to visualise its structure at the atomic scale using cryo-electron microscopy.

Electron microscopy allows us to visualise exactly how these drugs bind inside the carrier to jam it -- a spanner in the works, you could say.

This creates new opportunities for structure-based drug design in order to develop better, more targeted drugs.

The research was supported by the Medical Research Council .

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